Yvonne Shyntum, J.D., Ph.D., serves as a Partner in the areas of biotechnology and pharmaceuticals.
Yvonne manages patent portfolios across the full prosecution lifecycle, from drafting and filing U.S. patent applications through responses, amendments, and office action strategy to allowance. Her practice also includes representing clients before the Patent Trial and Appeal Board (PTAB) in appeals, both for matters she has prosecuted herself and for matters originally handled by other attorneys. In addition to prosecution, she drafts invalidity, freedom-to-operate, and non-infringement opinion letters and prosecutes trademark applications across industries beyond life sciences. To help clients pursue patent protection in foreign jurisdictions, she partners with a select group of attorneys around the globe.
Yvonne's practice throughout her career has centered on synthetic biology and pathway engineering. She has done extensive work on genetically engineering metabolic pathways, combining existing biological systems or building new ones to give organisms abilities they did not have before. This included roughly a decade of prosecuting applications related to engineering bacteria, and later plants, to manufacture polyhydroxyalkanoate (PHA) bioplastics. That work was later carried over into materials science, helping to develop biodegradable products now in commercial use. Yvonne‘ has also done extensive work biologics, including cell-therapy, developing strategies to distinguish chemically induced cells from naturally occurring counterparts. A steady stream of drug-delivery work, focused on improving the pharmacokinetics of therapeutics, rounds out her practice.
Yvonne earned her Ph.D. in pharmacology before going to law school. She chose to become an attorney for the professional flexibility it offered beyond patent prosecution, such as opinion work, and trademark practice. Born in Cameroon, Yvonne studied in part in Nigeria before moving to the United States. She brings a global perspective to her practice and looks for every opportunity to travel and learn about the world by meeting people from different cultures, a practice she fondly calls the University of Life.
Key Matters
Synthetic Biology & Metabolic Pathway Engineering
Obtained a patent for a small-molecule method that reprograms adult cells into pluripotent stem cells without genetic modification (U.S. Patent No. 12,180,509).
Prosecuting a pending application for metabolite compositions that shift differentiated cells into a progenitor-like state.
Obtained a patent for a carotenoid-based method that promotes crop growth and suppresses parasitic weed germination by regulating a plant hormone pathway (U.S. Patent No. 11,839,210).
Prosecuting a pending application for transgenic rice engineered to increase grain size and lipid content.
Bio-Based & Biodegradable Materials
Obtained a patent for transplastomic plants engineered to produce bioplastic directly in their leaves at commercial yields (U.S. Patent No. 9,096,861).
Obtained a patent for resorbable surgical meshes, implants, and fibers made from a biodegradable polyester (U.S. Patent No. 10,994,057).
Prosecuting allowed application on antimicorbial bidomain peptide.
Drug Delivery
Prosecuting a pending application for polymer-drug conjugates that extend release of anti-VEGF therapy in the eye to treat macular degeneration.
Prosecuting a pending application for dendrimer-based delivery systems that target therapeutics to neurons.
Prosecuting a pending application for engineered peptide carriers for controlled drug delivery.
Obtained two patents for absorbable polymer stent coatings combining radial strength with controlled drug elution (U.S. Patent Nos. 8,979,921 and 9,592,325).
Obtained a patent for a stabilized glucagon formulation used in emergency treatment of severe hypoglycemia (U.S. Patent No. 9,610,329).
Engineered Cells, Antibodies & Biologics
Prosecuting a pending application for a chimeric antibody platform built from lamprey-derived variable lymphocyte receptors.
Obtained paten for vaginal microbiota formulation for to restore normal cervicovaginal microflora in a recipient in need thereof, securing a patent after the examiner was reversed on appeal. (U.S. Patent No. 12005089)
Obtained patent on an antibody or an antigen-binding fragment thereof that specifically binds to CD47 (U.S. Patent No. 12,703,743)
Prosecuting allowed application on An antibody or an antigen-binding fragment thereof binding to IL4RA
PTAB Appeals Highlights
Successfully appealed rejection of claims to vaginal microbiota formulation for to restore normal cervicovaginal microflora in a recipient in need thereof, securing a patent after the examiner was reversed on appeal. (U.S. Patent No. 12005089)
Successfully appealed rejection of claims to an isolated tumor cell population used in personalized T-cell cancer therapy, securing a patent after the examiner was reversed on appeal. (U.S. Patent No. 10,247,731)
Successfully appealed rejection of a parathyroid hormone bone-graft formulation for spinal fusion, securing a patent after the examiner was reversed on appeal. (U.S. Patent No. 10,589,001)
Cross-Industry Range
Prosecuting a pending application for plant-based frozen confection formulations.
Obtained a patent for nanocomposite membrane (NCM) for membrane distillation, the NCM comprising: polymer fibers aggregated into a matrix; and periodic mesoporous organosilica (PMO) nanoparticles disposed on the polymer fiber (U.S. Patent No. 11,260,352).
Obtained a patent A wastewater treatment system comprising an aerobic granular sludge (AGS) tank coupled to a gravity-driven membrane (GDM) tank comprising one or more gravity-driven membrane(s) (U.S. Patent No. 12,378,142)
Prosecuting allowed application on Nanobody Functionalized Electrochemical Transistors And Methods Of Making And Using Thereof
Prosecuting pending applications for rare-earth magnet compositions with improved magnetic performance.
Prosecuted pending application for amino acid-supplemented cement admixtures with improved mechanical properties.
Prosecuting a pending application for a membrane-based wastewater treatment system using aerobic granular sludge.